Amphisbaena is the name of the gambling ring Izaya Orihara started in high school along with Nakura. Izaya abandoned it when he became bored, and Earthworm, who was previously a representative of Izaya and Nakura, took control and transformed it into a gambling parlor. Amphisbaena become rivals with Heaven's Slave and are later taken over by Dragon Zombie.
- Amphisbaena probably gets its name from the creature of Greek mythology; an ant-eating serpent with a head at each end. Its name comes from the Greek words amphis meaning "both ways" and bainein meaning "to go." According to Greek mythology, the amphisbaena was spawned from the blood that dripped from the Gorgon Medusa's head as Perseus flew over the Libyan Desert with it in his hand, after which Cato's army encountered it along with other serpents on the march. Amphisbaenae fed off of the corpses left behind.